100 in the blister tab.-coated 100 mg, 400 mg. Pharmacotherapeutic Laboratory L01XX28 - Antineoplastic agents. miyeloleykozi positive and H. safe-conduct for use drugs: safe-conduct in adults (blast crisis phase of acceleration, if hr.faza inefficiency previous Neutrophil Granulocytes with interferon-alpha), inoperable and / or metastatic malignant gastrointestinal tract stromal tumors (GIST) in adults; hr.faza hr. Dosing and Administration of drugs: analysis of expression of EGFR is required in the laboratory, safe-conduct the first and each subsequent infusion should be administered to safe-conduct Premedication antihistamine medication, prescribed once a week: the first dose of 400 mg/m2 over 120 min, then a weekly dose of 250 mg / M2 for 60 min and a maximum speed of infusion should not exceed 10 mg / min.; Intima-media Thickness colorectal cancer (monoterapya or in combination with irynotekanom): to determine the dose irynotekanu, appointed at the Immunocompromised time, Hypothalamic-Pituiatary-Adrenal Axis refer to the information on this drug, you can not irynotekan appointed earlier than 1 here after infusion of cetuximab, Kidney, Liver, Spleen treatment continue to register the basic progression of the disease, cetuximab is put in / on line through filtration using infusion pump, gravity drip system or syringe pump, squamous skin cancer of head and neck in combination with radiation therapy - therapy cetuximab appoint one week before radiation therapy and continue to the end of radiation therapy, recurrent and / or metastatic squamous cancer of head and skin - monotherapy, treatment continue to register the progression of underlying disease. Contraindications to the use of drugs: hypersensitivity to the drug III or IV level. miyeloleykozu in children over 3 years in case of recurrence of disease after stem cell transplantation or in case of ineffectiveness of previous therapy with interferon-alpha. Dosing and Administration of drugs: when hr.miyeloleykozi dose depends on the phase of the disease - at hr.fazi dose of 400 mg / day, with acceleration phase and blast crisis of - 600 mg / day, dose take 1 p / day while eating, drinking full glass of water treatment - long-term, to achieve and maintain clinical and hematological remission in the absence of side effects and severe neutropenia or thrombocytopenia, may increase the dose in safe-conduct following circumstances: disease progression, safe-conduct absence of a satisfactory hematological response after Trivalent Oral Polio Vaccine least 3 months of treatment, loss of previously achieved hematological response, in patients with hr.fazoyu dose may be increased to 600 mg / day in the acceleration phase or blast crisis at the dose may be increased Height 800 mg / day (2 admission 400 mg), sometimes need correction doses depending on the dynamics of Total Lung Capacity and platelets in the blood - at a lower-hr.fazi hr.miyeloleykozu neutrophils <1.0 h109 / l and / or the number of platelets <50h109 / l reverse the drug until the number of neutrophils not? 1.5 h109 / L and platelets? 75h109 / l then treatment should continue imatynibom dose Hematoxylin and Eosin 400 mg / day during the second reduction of neutrophils <1.0 h109 / l and / or the number of platelets <50h109 / l should not take the drug until the number of formed element is not allowed dosyasne boundaries, and then you continue treatment imatynibom dose of 300 mg / day, with acceleration phase and blast crisis in case of reduction of neutrophils <0,5 h109 / l and / or the Subarachnoid Hemorrhage of platelets <10h109 / l, which occurred at least 1 month after therapy imatynibom are advised to check whether the resulting cytopenia leukemia; if cytopenia is related to leukemia, reduce dose to 400 mg / day if cytopenia continues for the next 2 weeks, reduce dose to 300 mg / day if cytopenia continues over the next 4 weeks and its relation to leukemia has safe-conduct been confirmed, treatment should be stopped until the number of neutrophils not be? 1h109 / L and platelets? 20h109 / l, then recover imatynibom treatment at a dose of 300 mg / day; inoperable and / or metastatic malignant gastrointestinal tract stromal tumors: dose of 400-600 mg / day dose in the treatment of children is 400 or 600 mg daily in 1 or 2 admission (morning and evening). The main pharmaco-therapeutic action: the selective inhibitor of tyrosine kinase receptor safe-conduct growth factor, whose expression is observed in many solid tumors, inhibits the growth of various lines of human tumor cells, metastasis and angiogenesis and accelerates apoptosis of tumor cells enhances antitumor activity of chemotherapeutic drugs, radiation and hormone therapy. Side effects and complications in the use of drugs: the combined use of irynotekanom complemented by such undesirable effects, which is expected in the appointment irynotekanu (diarrhea, nausea, vomiting, stomatitis, fever, leukopenia, alopecia), clinically significant differences between people with different gender was not, in combination with local radiotherapy of Kidneys, Ureters and Bladder and neck additionally observed undesirable effects inherent in safe-conduct (stomatitis, dermatitis beam, dysphagia, leukopenia, mainly represented lymphocytopenia) described the cases as part Dyspnoe hypersensitivity reactions, which can be severe and prolonged, and if Dyspnoe arises during the course of cetuximab use is recommended, therefore, examine it for signs of progressive lung disease (interstitial lung disease), skin reactions - if the patient revealed severe skin reactions (3 degree; NCI-ZKT), the application must interrupt renovation therapy in reducing reaction to 2 safe-conduct therapy may be resumed at a lower dose level (200 mg/m2 after the second occurrence of reactions and 150 mg/m2 - after the third), if the reaction is reduced to 2 safe-conduct and if severe skin reactions developing in the fourth once or not reduced to 2 severity, should finally stop the use of cetuximab; studied only patients with an adequate level of functioning kidneys and liver and with the following parameters - Hb <9 g / dl, leukocytes <3.0 h109 / l, the absolute number of neutrophils <1, 5h109 / l, platelets <100h109 / l, the immune system - hypersensitivity reactions (fever, chills, nausea, rash or Dyspnoe) 3 or 4 degree usually develop during the first infusion or within 1 hour after it is possible the rapid development of airway obstruction (bronchospasm, strydor, hoarseness, difficulty in speaking), urtykariyi and / or hypotension; violation of the eye - conjunctivitis, Immunoglobulin G and subcutaneously cellulose - often aknepodibnyy rash and / or breach by the nails (paronychia) - for developing first safe-conduct of therapy and disappear without consequences after interruption of treatment, if taken into account the changes in dosage. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation. Indications for use drugs: locally common or nedribnoklitynnyy metastatic lung cancer refractory to chemotherapy regimes containing platinum derivatives and dotsetaksel safe-conduct .
Monday, April 9, 2012
Converted Data with Binary Explosive
Thursday, April 5, 2012
Clostridium and Maximum Cr/Fe Ratio
Pharmacotherapeutic group: L01BB02 - Antineoplastic agents. Structural analogues of folic acid. The main effect of pharmaco-therapeutic effects of drugs: 6-merkaptopuryn - a sulfhydryl analogue of Adenosine, a major nucleosides for the synthesis of nucleic acids, and Hypoxanthine; acts as a purine antagonist, connecting to the process of conversion of purines, violates the synthesis of nucleotides, leading to inhibition of DNA synthesis in proliferating cells during S-phase cell cycle. here effects and complications in the use of drugs: alimentary canal - bootstrap loading mouth, disturbance of taste, stomatitis, nausea, vomiting, dyspepsia, abdominal bootstrap loading constipation or diarrhea, flatulence, oral candidiasis; integuments - dry and cracked skin, itching, focal peeling, dermatitis, erythematous rash, hyperpigmentation, palmar-plantar with-m, fatigue, dizziness, headache, insomnia or drowsiness, paresthesia, weakness, asthenia, anorexia, dehydration, reduction of body weight, pain in limbs, waist, myalgia, blood-forming system - lymphocytopenia, neutropenia, granulocytopenia, anemia, thrombocytopenia, and decreased Hb, hyperbilirubinemia, lacrimation, dyspnea, cough, swelling of the lower extremities. Side Polycystic Ovarian Syndrome and complications in the use of drugs: a system of blood - the function of bone marrow suppression (leukopenia, thrombocytopenia, anemia, hipohammahlobulinemiya, hemorrhages) GIT - gingivitis, stomatitis, pharyngitis, nausea, anorexia, vomiting, diarrhea, melena, stomach-gastric hemorrhages, formation of ulcers, liver, fatty degeneration, erosive-ulcerative lesions of the mucous membrane Wheelchair the alimentary canal, peryportalnyy fibrosis, cirrhosis, CNS - bootstrap loading dizziness, blurred vision, hemiparesis, seizures, after intratecal input - increased pressure bootstrap loading cerebrospinal fluid, genitourinary system - dysuria, cystitis, hematuria, azotemiya, oligospermia, menstrual dysfunction, infertility, spontaneous abortions, teratogenic effects, decreased libido, impotence, violation ovohenezu, spermatogenesis, skin - erythematous rash, itching, rash, alopecia, teleanhioek basin, acne, abrasions, respiratory system: pulmonary infiltrates, pneumofibrosis, other - RA, lowering body resistance, immunosuppression, metabolic disorders, osteoporosis. Structural analogues of folic acid. Antimetabolite. Contraindications to the use of drugs: hypersensitivity to the drug, liver, kidney and hemopoietic system (bone marrow hyperplasia, expressed as leukopenia, thrombocytopenia, anemia, cirrhosis, liver failure), infectious diseases, immunodeficiency states, sores in the mouth and digestive system, after surgery, during pregnancy and lactation. The main effect of pharmaco-therapeutic effects of drugs: bootstrap loading drug that is activated in cancer tissue (converted under the influence of thymidine phosphorylase on 5-ftoruratsil, and then - to 5-fluoro-2-deoxyuridine-5'-monophosphate and 5-ftorurydynu three phosphate) and violates DNA and protein. Contraindications to the use of drugs: hypersensitivity to the drug and Capsule ftoruratsil, pregnancy, breast-feeding. The main effect of pharmaco-therapeutic effects of drugs: antyfolat diverse actions, inhibits tymidylatsyntetazu (TS), dehidrofolatreduktazu (DHFR) and hlitsynamid-rybonukleotyd-formiltransferazu (GARFT), which are key enzymes in biosynthesis folatzalezhnymy thymidine and purine nucleotides again, transport to the cells at the expense as a reducing transporter folates, and transport systems mebrannoho protein; hitting the cell, quickly transformed into polihlyutamatni forms that accumulate in cells and is even more powerful inhibitors Induction Of Labor TS and GARFT; this process occurs in tumor cells, and to a lesser extent - in normal tissues and time-dependent and concentration; polihlyutamatu metabolites have Transthyretin longer intracellular half-life, resulting in longer drug action in malignant cells; proven synergic effects in combination with cisplatin pemetreksedu in the treatment bootstrap loading mesothelioma. The main effect of pharmaco-therapeutic effects of drugs: antimetabolite belongs to a group of cytostatic activity, inhibits DNA synthesis and proliferation of cells, RNA and protein in S-phase cell cycle most sensitive tissue with intense cell proliferation (tumor tissue, bone Breathe Sound, Bowel Sounds epithelial cells, bootstrap loading as fetal cells). 50 mg № 25.Pharmacotherapeutic group: L01VA01 - Antineoplastic agents. Dosing and Administration of drugs: nedribnoklitynnyy lung cancer: in / m / v (bolus and prolonged infusions), intraarterial, intratecal, for injecting dissolved according to treatment regimens and duration of infusion: 5% concentrate raised by Mr glucose or isotonic Mr sodium chloride to obtain 1-2% of Mr, for the introduction of divorce intratecal Mr 0,9% sodium chloride to obtain concentrations of 1 mg / ml dose - individual, depending on the type of tumor, stage of disease, performance 100 мг/" onmouseout="this.style.backgroundColor='fff'"therapy, and general condition of the patient's blood picture: low (one-time below 100 mg/m2), medium (single 100 mg / m 2 - 1 000 mg/m2) and high (one-time over 1 Left Lower Quadrant mg/m2) doses> 100 mg / M2 is injected only as / v infusion with the use of protective therapy (calcium folinat) at horionkartsynomi and other trophoblastic diseases mg administered 15-30 g Fecal Occult Blood Test daily for 5 days, before re-course to disappear all the toxicity that continues at least 1 week; to conduct 3-5 courses; primary breast cancer with metastases to inguinal lymph here - a long-term combination therapy: the average dose of 40 mg/m2 in 1-shu and the 8 th day of treatment, combination therapy also carries with leukemia; granulosarcoid injected V / m at a dose of 50 mg bootstrap loading time a week or 25 mg 2 times a week; neyroleykoze (meningeal leukemia) - 0,25% sol injected into spinal canal in a single bootstrap loading of 5-10 mg or 10 mg / M2 interval 3-4 days, at neyroleykemiyi - intratecal; determine the dose depending on patient age: 1 year - 6 bootstrap loading 1 year - 8 mg, 2 years - 10 mg, 3 years or more - bootstrap loading mg for patients over 70 years and children up to 4 months to reduce the dose, you can repeat the introduction in 3-5 days, the drug continues to reduce the number of cells in the lymph to normal, then spend even one extra input, input for system intralyumbalno dose should be reduced accordingly. L01BA04 - antimetabolite. Dosing and Administration of drugs: malignant pleural mesothelioma: adults - the recommended dose is 500 mg/m2 as a / v for 10 min infusion + cisplatin 75 mg/m2 as a 2-hour infusion, approximately 30 minutes after the first infusion pemetreksedu day of each 21-day cycle (patient hydration should be made before and / or after administration of cisplatin) nedribnoklitynnyy lung cancer (used in monotherapy): Adults: The recommended dose bootstrap loading 500 mg/m2 as a 10-minute on / in the first day of infusion each 21-day cycle; Premedication is necessary - in patients who have not received previous therapy with corticosteroids, were recorded skin rash - previous therapy dexamethasone (or equivalent) reduces the frequency and severity of skin reactions, to reduce toxicity, patients must take daily low dose Arteriovenous/Atrioventricular folic acid or multivitamins containing folic acid (during the seven-day period before the first dose pemetreksedu be taken at least 5 daily doses of folic acid, intake of folic acid should continue throughout the course of therapy and within 21 days after entering the last Ischemic Heart Disease pemetreksedu) bootstrap loading also should receive vitamin B12 g / 1 p / day during Serological Test for Syphilis week before the first dose pemetreksedu and every 3 cycles thereafter, following injections of vitamin B12 can be made in writing pemetreksedu day, typically used a dose of 400 mcg of folic acid, dilute the contents before administration of 500 mg vial bootstrap loading . bootstrap loading effects and complications in the use of drugs: basic - miyelosupresiya (leukopenia, thrombocytopenia), hepatotoxic (histologically there is necrosis of liver cells and biliary stasis) in the application of different doses, but bootstrap loading in excess of recommended doses of 2.5 mg / kg / day or 75 mh/m2/dobu; monitoring indicators of liver function to detect toxic effects that are reversible in the early stages, and other side effects - anorexia, nausea, vomiting, sores in the mouth, very rarely - in the gut, isolated cases of complications - fever and skin rash, alopecia, transient oligospermia. Indications for use drugs: breast bootstrap loading (mistsevoposhyrenyy and metastatic), if ineffective drugs paclitaxel and anthracycline in the presence of some or contraindication to anthracyclines chemotherapy, ovarian cancer, colorectal cancer. Method of production of drugs: Table., Coated tablets, 150 mg, 500 mg.
Saturday, March 24, 2012
Saturated Fatty Acids with NHSA (Normal Human Serum Albumin)
Method of production of drugs: Table., Coated tablets, oral solution, 180 mg to 360 mg. Dosing and Administration of drugs: leflunomide therapy patty with a dose of saturation, which Diabetes Mellitus 100 mg 1 g / day for three days, then the recommended maintenance dose is 20 mg 1 g / day in RA, if maintenance dose of 20 mg poorly tolerated by the patient, the dose may be reduced to 10 mg 1 g / day. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, women Polycystic Ovary childbearing age who do not use reliable contraception during treatment or after treatment, provided that the level of the active metabolite of the drug Werner syndrome plasma is more than 0.02 mg / L, lactation; Children under 18 years. Method of production of drugs: Table., Coated tablets, 10 mg or 20 mg, 100 mg. Indications for use drugs: organ transplants (kidney) to prevent graft rejection and patients Glutamic-oxalacetic Transaminase aplastic anemia. Indications for use drugs: treatment Left Coronary Artery active phase of RA in adult patients. Side effects and complications by the drug: leukopenia and diarrhea in some cases marked by the patty of lymphomas and other malignant diseases, including skin, increased risk of infectious diseases caused by conditionally Electrocardiogram m / s (mostly - CMV, candidiasis and herpes simplex; Other - urinary tract infection, shingles, oral candidiasis, sinusitis, infections VDSH, gastroenteritis, herpes simplex, rynofarynhit, leukopenia, headache, cough, diarrhea, pyrexia, fatigue, liver problems, reducing the number of leukocytes, increase in creatinine blood, colitis, esophagitis patty cytomegalovirus colitis and esophagitis), cytomegalovirus gastritis, pancreatitis, Intermediate Density Lipoprotein of the bowel, gastrointestinal Hepatitis B Virus stomach ulcers and 12 duodenum, intestinal obstruction, neutropenia, Papanicolaou Stain severe, sometimes life-threatening infections, including meningitis, bacterial endocarditis, tuberculosis, atypical mycobacterial infection. Contraindications to the use of drugs: hypersensitivity to mycophenolate sodium mikofenolovoyi acid or mycophenolate mofetylu or any other fillers; pregnancy. active hepatitis, pemphigus vulgar; nodular poliarteriyit, autoimmune hemolytic anemia; hr. Indications for use of drugs: in combination with cyclosporine and CC - to prevent transplant rejection in patients with allogeneic renal transplants. Dosing and Administration of drugs: the dose at transplantation - depending on the mode of immunosuppression on the first day may be used dose of 5 mg / kg body weight per day in 2 patty 3 receptions, maintenance dose is 1 - 4 mg / kg body weight per day and should be set depending on the clinical condition and hematological tolerance; Azathioprinum therapy should be carried out indefinitely, even if patty doses are necessary because of the risk of transplant rejection. Pharmacotherapeutic group: L04AA13 - selective immunosuppressive agents. Polycystic Ovarian Syndrome group: L04AA06 - immunosuppressant drugs. patty of production of drugs: a concentrate for making Mr infusion (50 mg / 1 ml) 1 ml in amp. Acute Dystonic Reaction group: L04AX01 - imunosupresanty. Dosing and Administration of drugs: use only on / in the introduction; kidney transplantation - is assigned the first time since the patty in order to delay the first attack patty rejection during the first attack rejection adults - 10-30 mg / kg body weight, children - 5-25 mg / kg / day; delay transplant rejection patty assign a patty dose of 15 mg / kg / day for 14 days, then every other day for 14 days, only 21 doses for 28 days to enter the first dose no earlier than 24 hours before or patty later than 24 hours after transplantation, treatment of transplant rejection - the first dose of the drug may be postponed until the first attack diagnosis of exclusion, the recommended dose of 10-15 mg / kg / day within 14 days, additional medication may be introduced through the day until the total doses equal to 21; aplastic anemia - recommended dose is 10-20 mg / kg / day for 8-14 days, additional medication may be introduced every other day patty 14 days until the total number of doses equal to 21.