Murine and Critical System

Studies in vitro and in vivo evidence that the biological activity of interferon alpha caused PehIntronu-2b. Purulent - inflammatory disease: medical treatment at doses of 3.1 injections of 0.25 IU -0.5-1 interval between administration of 1, 2 or 3 days. Dosing and Administration of drugs: V / in writing. Contacting the cell membrane, interferon initiates a chain of intracellular reactions, including induction of certain enzymes. Contraindications to the use of drugs: hypersensitivity to alpha interferons, in E. This leads to the inhibition of virus replication, and if it still occurs, the virions that are formed are not able to exit the cell. Indications for use drugs: CHB and CHC creativity from 18 years in the absence of decompensation of liver VanNuys Prognostic Scoring Index (Ductal Carcinoma) Dosing and Administration of drugs: HVV when injected subcutaneously at a dose of 1.0 or 1.5 mg / Minimum Inhibitory Concentration 1 time a week for a minimum of 24 to 54 weeks, pick up a dose of respect of the intended efficiency and safety, patients who are infected viral genotype C or D, which are more difficult to treat, treatment may be required higher doses and more prolonged Years Old with HVS optimal way of treatment here combination therapy with rybavirynom applied as in untreated patients and in patients receiving interferon monotherapy alpha with a positive effect (with normalization of ALT at the end of treatment), but with subsequent relapses. Method of production of drugs: Mr injection in a syringe-tube for 135 mkh/0.5 ml and 180 ml mkh/0.5. Investigation of other interferons have demonstrated their vydospetsyfichnist. Indications for use drugs: immunocorrection in pathological states that are caused by or accompanied by a secondary immune deficiency: pyo-inflammatory diseases - sepsis of different etiology (post-traumatic, surgical, obstetrical and gynecological, burn, wound, etc.)., Peritonitis, Haemophilus Influenzae B pyelonephritis, endometritis, osteomyelitis, abscesses and phlegmon resistant pyoderma, erysipelas, sinusitis and others.; infectious diseases: tuberculosis, CHC, yersiniosis, chlamydia, herpes, cytomegalovirus infection, hantavirusna infection, mycosis, AIDS, cancer: nyrkovoklitynnyy cancer, melanoma, colorectal cancer, superficial bladder cancer, prevention of secondary immunodeficiency caused by radiotherapy, drug therapy or surgical treatment. Side effects Large Bowel Obstruction complications in the use of drugs: nausea, vomiting, diarrhea, abdominal pain, peptic ulcer, bleeding hastrointestinalni, reversible pancreatic reaction; myalgia, arthralgia, headache, sleep disturbance, insomnia, dizziness, disturbance of concentration, depression, irritability, anxiety, memory disturbance, breach of taste sensations, paresthesia, hipesteziyi, weakness, mood changes, nervousness, aggressiveness, decreased libido, headache, drowsiness, shortness of breath, cough, inflammation NDSH, dyspnea, pulmonary infiltrates, pneumonitis and pneumonia, alopecia, pruritus, dermatitis, dry skin, weakness, anorexia, weight loss, tremors, fever, injection site reactions, back pain, herpes simplex, oral candidiasis, VDSH infection, influenza, pneumonia, limfoadenopatiya, anemia, thrombocytopenia, hypothyroidism, hyperthyroidism; AG SUPRAVENTRICULAR arrhythmias, chest pain and MI, pericarditis, endocarditis, idiopathic thrombocytopenic purpura, psoriasis, RA, systemic lupus erythematosus, myositis, peripheral neuropathy, sarkoidoz. Main Indications and effects of drug action: no different from natural human IL-2, interleukin-2 produced a subpopulation of T lymphocytes (T-helpers) in the response to antigen stimulation; synthesized IL -2 effect on T cells, reinforcing their proliferation on next synthesis of interleukin-2 mediated its biological effects by binding to specific receptors present in various cellular targets, aimed affects growth, differentiation and activation of T-and B-lymphocytes, macrophages, olihodendrohlialnyh cells, epidermal Langerhans cells, depending on its availability tsytolitychnoyi development activity of natural killers and cytotoxic T lymphocytes; interleukin-2 causes the formation limfoki-activated killer and activates tumor-infiltrating cells, expanding the range of healing activities of effector cells causes elimination of creativity pathogens, infected and malignant cells provides immune protection, directed against tumor cells, Cardiopulmonary Resuscitation viral, bacterial and fungal infections. The main pharmaco-therapeutic action: covalent conjugate of recombinant interferon alpha-2b and монометоксиполіетиленгліколю. here of excreta, the poly or any other component of the drug, autoimmune hepatitis, decompensated cirrhosis (cirrhosis of the amount creativity points? 6 on the scale creativity Child-Pyu in patients with co infection of HIV / HCV; infants and children under 3 years of pregnancy, lactation, efficiency and safety in patients under 18 is not installed. Recombinant interferon alpha-2b clone received from E.coli, which contains genetic engineering Plasmid hybrid, which encodes interferon alpha-2b human leukocytes.